منابع مشابه
Uptake carriers and oncology drug safety.
Members of the solute carrier (SLC) family of transporters are responsible for the cellular influx of a broad range of endogenous compounds and xenobiotics in multiple tissues. Many of these transporters are highly expressed in the gastrointestinal tract, liver, and kidney and are considered to be of particular importance in governing drug absorption, elimination, and cellular sensitivity of sp...
متن کاملCardiac safety, risk management, and oncology drug development.
Cardiac safety biomarkers are increasingly employed in the preclinical and clinical development of investigational oncology products. Irrespective of overt clinical toxicities, cardiacrelated laboratory tests can influence decision making at many levels during the conduct of clinical studies, including eligibility for protocol therapy, dose delivery or discontinuation, and analyses of optimal d...
متن کاملCellular Uptake and Intracellular Cargo Release From Dextran Based Nanogel Drug Carriers.
Nanogels (NG) hold great promise as a drug delivery platform. In this work, we examine the potential of lysozyme-dextran nanogels (LDNG) as drug carriers in vitro using two cell lines: a model target tissue, human umbilical cord vein endothelial cells (HUVEC) and a model of the mononuclear phagocyte system (phorbol 12-myristate 13-acetate (PMA)-stimulated THP-1 cells). The LDNG (∼100 nm) were p...
متن کاملHPMA-LMA copolymer drug carriers in oncology: an in vivo PET study to assess the tumor line-specific polymer uptake and body distribution.
Polymeric drug carriers aim to selectively target tumors in combination with protecting normal tissue. In this regard polymer structure and molecular weight are key factors considering organ distribution and tumor accumulation of the polymeric drug delivery system. Four different HPMA based copolymer structures (random as well as block copolymers with lauryl methacrylate as hydrophobic block) v...
متن کاملColloidal Drug Carriers
Colloidal drug carrier is one of the most important entities essentially required for successful transport of loaded drugs. They are drug vectors, which sequester, transport and retain the active drug en route, while they elute or deliver it within or in the vicinity of target. Targeting the drug to the desired site of action would not only improve the therapeutic efficacy but also enable a red...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2013
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.113.055806